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Interoception as a central mechanism in Whole Person Health
by Wen G. Chen, Helene M. Langevin Interoception may be a key mechanism in “Whole Person Health.” More and better technologies, tools, and mechanistic research are need...
Evolving life-history traits promote biodiversity via eco-evolutionary feedback mechanisms
by P. Catalina Chaparro-Pedraza, Claudia Bank To what extent is biodiversity shaped by environmental conditions, and to what extent is it the result of self-organizatio...
The body sends a signal: Perspectives on interoception
by Lucas K. Smith, on behalf of the PLOS Biology staff editors Research into brain–body communication is being reinvigorated as the field unites under the umbrella of “...
Cell2Spatial is a computational framework that maps single cells to spatial transcriptomic spots to reconstruct tissue architecture
by Huamei Li, Jingchao Liu, Guige Wang, Zhenyu Liu, Meng Cao, Lingyun Sun, Cheng Peng, Yiyao Liu, Liang Ma, Qing Xiong Single-cell (SC) sequencing enables detailed char...
The blood–brain barrier regulates brain tumor growth through the SLC36 amino acid transporter Pathetic in <i>Drosophila</i>
by Qian Dong, Edel Alvarez-Ochoa, Phuong-Khanh Nguyen, Paul Orih, Natasha Fahey-Lozano, Hina Kosakamoto, Fumiaki Obata, Cyrille Alexandre, Louise Y. Cheng Tumors adapt...
Hydroxyurea induces an oxidative stress response that triggers ER expansion and cytoplasmic protein aggregation
by Ana Sánchez-Molina, Manuel Bernal, Joel D. Posligua-García, Antonio J. Pérez-Pulido, Laura de Cubas, Elena Hidalgo, M. -Henar Valdivieso, Silvia Salas-Pino, Rafael R...
Chromosome duplication causes premature aging via defects in ribosome quality control
by Leah E. Escalante, James Hose, Jamie M. Ahrens, Hollis Howe, Norah Paulsen, Sofia J. Liss, Michael Place, Audrey P. Gasch Down syndrome, caused by an extra copy of C...
Transient frontopolar cortex stimulation induces prolonged disruption to counterfactual processing
by Matthew Ainsworth, Juan M. Galeazzi, Carlos Pedreira, Mark G. Stokes, Mark J. Buckley Frontopolar cortex (FPC) contains area 10, an anterior sub-region of prefrontal...
Bacterial immune systems as causes and consequences of microbiome structure
by Rafael Custodio, Ellinor O. Alseth, Michael A. Brockhurst, Sam P. Brown, Edze R. Westra Attacks from molecular parasites such as mobile genetic elements (MGEs) have...
Development of bitopic nanobody-ligand conjugates targeting G protein-coupled receptors and exhibiting logic-gated signaling
by Shivani Sachdev, Swarnali Roy, Ross W. Cheloha G protein-coupled receptors (GPCRs) are the largest family of plasma membrane-embedded signaling proteins. These recep...
Sleep deprivation and sleep intensity exert distinct effects on cerebral vasomotion and brain pulsations driven by the respiratory and cardiac cycles
by Sara Marie Ulv Larsen, Sebastian Camillo Holst, Anders Stevnhoved Olsen, Brice Ozenne, Dorte Bonde Zilstorff, Kristoffer Brendstrup-Brix, Pia Weikop, Simone Pleinert...
Diverse biophysical and molecular mechanisms drive phytoplankton sinking in response to starvation
by Yanqi Wu, Vieyiti K. Kouadio, Thomas R. Usherwood, Justin Li, Margaret Bisher, Reshum Aurora, Aaron Z. Lam, Alice R. Lam, Abigail K. R. Lytton-Jean, Scott R. Manalis...
Eye blinks synchronize with musical beats during music listening
by Yiyang Wu, Xiangbin Teng, Yi Du Auditory-motor synchronization, the alignment of body movements with rhythmic patterns in music, is a universal human behavior, yet i...
STUPPIT is a proximity labeling tool for labeling intermediary proteins that bridge two non-interacting proteins
by Lin Xie, Lijuan Gao, Weihong Fu, Gangyun Wu, Hua Li, Wenxiu Ning Decoding the complexities of signaling pathways is fundamental for deciphering the mechanisms underl...
Editorial Note: Global Regulator SATB1 Recruits β-Catenin and Regulates T<sub>H</sub>2 Differentiation in Wnt-Dependent Manner
by The PLOS Biology Editors
RNG2 tethers the conoid to the apical polar ring in <i>Toxoplasma gondii</i> to enable parasite motility and invasion
by Romuald Haase, Bingjian Ren, Albert Tell i Puig, Alessandro Bonavoglia, Jean-Baptiste Marq, Rémy Visentin, Nicolas Dos Santos Pacheco, Bohumil Maco, Ricardo Mondragó...
The cell cycle regulator PLK1 promotes murine melanoma progression by regulating the transcription factor BACH1
by Fengyi Mao, Sai Wu, Derek B. Allison, Daheng He, Yifan Kong, Chaohao Li, Zhiguo Li, Yanquan Zhang, Xinyi Wang, Qiongsi Zhang, Chi Wang, Xiaoqi Liu Polo-like kinase 1...
Amyloid precursor protein modulates cerebellar Purkinje cell activity and motor function through regulation of Nav1.6 currents
by Miao-Jin Ji, Tong-Xuan Wu, Chenhao Tian, Xiang Cao, Ruyuan Wei, Yin-Yin Yang, Xinran Meng, Huanyao Tang, Tiantao Cui, Jiao Yang, Xin Tang, Chao Liu Amyloid precursor...
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