PLoS Biology November 25, 2025

RNG2 tethers the conoid to the apical polar ring in <i>Toxoplasma gondii</i> to enable parasite motility and invasion

by Romuald Haase, Bingjian Ren, Albert Tell i Puig, Alessandro Bonavoglia, Jean-Baptiste Marq, Rémy Visentin, Nicolas Dos Santos Pacheco, Bohumil Maco, Ricardo Mondragón-Flores, Oscar Vadas, Dominique Soldati-Favre The conoid is a dynamic, tubulin-based structure conserved across the Apicomplexa that undergoes extrusion during egress, gliding motility, and invasion in Toxoplasma gondii. This organelle traverses the apical polar ring (APR) in response to calcium waves and plays a critical role i