by Miao-Jin Ji, Tong-Xuan Wu, Chenhao Tian, Xiang Cao, Ruyuan Wei, Yin-Yin Yang, Xinran Meng, Huanyao Tang, Tiantao Cui, Jiao Yang, Xin Tang, Chao Liu
Amyloid precursor protein (APP)-null mice exhibit significant deficits in motor performance, including reduced grip strength and impaired locomotion; however, the underlying neurophysiological mechanisms remain unclear. In this study, we show that conditional knockdown of APP selectively in Purkinje cells (PCs) recapitulates these motor deficits,