Cell2Spatial is a computational framework that maps single cells to spatial transcriptomic spots to reconstruct tissue architecture

by Huamei Li, Jingchao Liu, Guige Wang, Zhenyu Liu, Meng Cao, Lingyun Sun, Cheng Peng, Yiyao Liu, Liang Ma, Qing Xiong Single-cell (SC) sequencing enables detailed characterization of transcriptional heterogeneity but lacks spatial context, while spatial transcriptomics (ST) preserves tissue organization yet is limited by resolution and incomplete gene capture. To bridge these gaps, we developed Cell2Spatial, a computational framework that segments spatial spots at single-cell resolution, even