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果蝇tRNA库进化中性别偏向性重复快速产生
Eukaryotic genomes encode hundreds of transfer RNA genes ostensibly to ensure efficient translation. How these seemingly redundant tRNA copies arise and are naturally s...
芽孢杆菌感受态菌毛是高效摄取单链和双链DNA的机制
Natural competence describes the ability of several bacterial species to take up DNA from the environment for integration into the host chromosome, allowing the acquisi...
TA25——塔巴胺A衍生物在体外及计算机模拟中对人鼻病毒及多种人畜共患病毒的抗病毒与抗炎作用研究
Human rhinovirus (HRV), first isolated in 1956, belongs to the family Piconaviridae containing a positive-sense, single-stranded RNA genome. HRV causes mild cold and se...
通用大语言模型如DeepSeek V3.2已进化出蛋白质设计能力
General-Purpose Large Language Models (GLLMs), although primarily developed for natural language processing, are increasingly demonstrating emergent capabilities in spe...
假单胞菌KT2440降解木质素并实现其增值：谷胱甘肽过氧化物酶新功能的发现
Lignin, a complex natural aromatic polymer, poses significant challenges to its efficient degradation, hindering the utilization of biomass for many industrial applicat...
甲烷八叠球菌中的组蛋白与类核相关蛋白介导应激与休眠后的恢复过程
Many archaea encode both histones and Nucleoid-Associated Proteins (NAPs), which we refer to collectively as archaeal DNA Binding Proteins (DBPs). Whether these DBPs jo...
mRNA衰变率的生物物理限制塑造稳态丰度中的宏观进化差异
Evolutionary changes to gene expression are understood to be a major driver of phenotypic divergence between species. Researchers have investigated the drivers of this...
沿海沉积物中黄杆菌缓冲部分反硝化菌产生的一氧化二氮排放
Nearly one-fifth of global emissions of the potent greenhouse gas nitrous oxide (N2O) originate from the ocean, particularly from nutrient-polluted coastal regions. Per...
甘油通过非转录机制抑制化脓链球菌的乳糖依赖性生长
Streptococcus pyogenes (group A Streptococcus; GAS) requires flexible metabolic regulation to adapt to diverse host environments; however, its physiological responses t...
用于治疗性疫苗接种的HIV病毒体捕获脂质体
HIV infection currently has no effective cures and requires lifelong antiretroviral treatments. Cures have failed due to HIVs immune evasion and rapid mutation rate. He...
一种古老珊瑚蛋白揭示抗病毒信号转导的替代进化路径
How antiviral immunity first arose in animals is a central question in evolutionary biology. Using the sea anemone Nematostella vectensis, we identify CARDIB, a previou...
噬菌体全基因组转座子诱变
Bacteriophages have genomes that span a wide size range, are densely packed with coding sequences, and frequently encode genes of unknown function. Classical forward ge...
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