bioRxiv 2025年11月25日

通用大语言模型如DeepSeek V3.2已进化出蛋白质设计能力

General-Purpose Large Language Models (GLLMs), although primarily developed for natural language processing, are increasingly demonstrating emergent capabilities in specialized scientific domains. In this study, we explored the potential of GLLMs, specifically DeepSeek V3.2 Exp in reasoning mode, to perform practical protein engineering tasks without domain-specific biological training. Two representative design problems were addressed: Generation of amino acid sequences predicted to adopt the c