PLoS Biology 2025年11月25日

RNA结合蛋白RBM39构建m⁶A依赖性RNA降解复合体,削弱Tat转录物稳定性并限制HIV-1再激活

by Xiaohui Deng, Siyi Xie, Mo Zhou, Quyu Yuan, Shuangxin Wu, Peiming Huang, Minghua Chen, Jianteng Zeng, Pengle Guo, Jie Qin, Cancan Chen, Jiaye Liu, Bingfeng Liu, Xin He, Liqin Sun, Hui Zhang, Linghua Li, Ting Pan The persistence of latent HIV-1 reservoirs remains a critical barrier to functional curing AIDS, as current latency-reversing agents (LRAs) exhibit limited clinical efficacy. While RNA modifications like N⁶-methyladenosine (m⁶A) regulate viral replication, their role in maintaining H