The RNA-binding protein RBM39 scaffolds an m⁶A-dependent RNA decay complex that destabilizes Tat transcripts and restricts HIV-1 reactivation

by Xiaohui Deng, Siyi Xie, Mo Zhou, Quyu Yuan, Shuangxin Wu, Peiming Huang, Minghua Chen, Jianteng Zeng, Pengle Guo, Jie Qin, Cancan Chen, Jiaye Liu, Bingfeng Liu, Xin He, Liqin Sun, Hui Zhang, Linghua Li, Ting Pan The persistence of latent HIV-1 reservoirs remains a critical barrier to functional curing AIDS, as current latency-reversing agents (LRAs) exhibit limited clinical efficacy. While RNA modifications like N⁶-methyladenosine (m⁶A) regulate viral replication, their role in maintaining H