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Targeting Metabolic Vulnerabilities: Valinomycin Augments the Potency of Bioenergetic Inhibitors in Combatting Drug-Resistant and Dormant Mycobacterium tuberculosis
Tuberculosis (TB) treatment is hampered by monotherapy limitations and phenotypic drug tolerance, citing the need for effective drug combinations. The mycobacterial ele...
Nomenclature updates to the hemagglutinin gene clade designations resulting from the continued evolution of high pathogenicity avian influenza A(H5) virus clades 2.3.2.1c and 2.3.4.4
The evolutionary divergence of the A(H5) hemagglutinin (HA) gene of high pathogenicity avian influenza (HPAI) viruses (A/goose/Guangdong/96 lineage) was analyzed by phy...
Glycerol suppresses lactose-dependent growth of Streptococcus pyogenes through a transcription-independent mechanism
Streptococcus pyogenes (group A Streptococcus; GAS) requires flexible metabolic regulation to adapt to diverse host environments; however, its physiological responses t...
HIV Virion Capturing Liposomes for Therapeutic Vaccination
HIV infection currently has no effective cures and requires lifelong antiretroviral treatments. Cures have failed due to HIVs immune evasion and rapid mutation rate. He...
Cell2Spatial is a computational framework that maps single cells to spatial transcriptomic spots to reconstruct tissue architecture
by Huamei Li, Jingchao Liu, Guige Wang, Zhenyu Liu, Meng Cao, Lingyun Sun, Cheng Peng, Yiyao Liu, Liang Ma, Qing Xiong Single-cell (SC) sequencing enables detailed char...
Bacterial immune systems as causes and consequences of microbiome structure
by Rafael Custodio, Ellinor O. Alseth, Michael A. Brockhurst, Sam P. Brown, Edze R. Westra Attacks from molecular parasites such as mobile genetic elements (MGEs) have...
Eye blinks synchronize with musical beats during music listening
by Yiyang Wu, Xiangbin Teng, Yi Du Auditory-motor synchronization, the alignment of body movements with rhythmic patterns in music, is a universal human behavior, yet i...
Human monoclonal antibodies targeting A35 protect from death caused by mpox
Publication date: 30 October 2025Source: Cell, Volume 188, Issue 22Author(s): Raianna F. Fantin, Meng Yuan, Seok-Chan Park, Bailey Bozarth, Hallie Cohn, Maxinne Ignacio...
Mapping chromatin structure at base-pair resolution unveils a unified model of <em>cis</em>-regulatory element interactions
Publication date: Available online 5 November 2025Source: CellAuthor(s): Hangpeng Li, James L.T. Dalgleish, George Lister, Maria Julia Maristany, Jan Huertas, Ana M. Do...
Pathway-selective 5-HT<sub>1A</sub>R agonist as a rapid antidepressant strategy
Publication date: Available online 12 November 2025Source: CellAuthor(s): Chunyu Wang, Nan Zhang, Yujie Shao, Tao Li, Mengna Zhang, Meng Gao, Yaqi Liang, Yumeng Wang, T...
<a href="https://www.fiercebiotech.com/pharma/gsks-tesaro-and-licensor-anaptysbio-lock-horns-court-over-jemperli-agreement" hreflang="en">GSK's Tesaro, AnaptysBio lock horns in court over Jemperli agreement</a>
Some four years into Jemperli’s commercial life span, a rift has emerged between GSK subsidiary Tesaro and the potential cancer blockbuster’s original developer, Anapty...
<a href="https://www.fiercebiotech.com/biotech/sarepta-shares-positive-safety-update-dm1-asset-arrowhead-hits-200m-milestone" hreflang="en">Sarepta shares positive safety update on DM1 asset as Arrowhead snares $200M milestone</a>
A drug safety group has delivered a positive analysis for a Sarepta-licensed RNA medicine, with the same study also hitting an enrollment target. The latter development...
Nations at COP30 must cancel fossil-fuel concessions to keep the Paris agreement in reach
Nature, Published online: 18 November 2025; doi:10.1038/d41586-025-03780-4Nations at COP30 must cancel fossil-fuel concessions to keep the Paris agreement in reach
Women seem to retract fewer papers than men — but why?
Nature, Published online: 19 November 2025; doi:10.1038/d41586-025-03796-wIn an analysis of nearly 900 retracted medical-research studies, the number of female authors...
Insulin cream offers needle-free option for diabetes
Nature, Published online: 19 November 2025; doi:10.1038/d41586-025-03803-0Skin-permeable polymer shows promise at insulin delivery in animal experiments — plus, how the...
Author Correction: A metallic <i>p</i>-wave magnet with commensurate spin helix
Nature, Published online: 19 November 2025; doi:10.1038/s41586-025-09861-8Author Correction: A metallic p-wave magnet with commensurate spin helix
A brain implant that could rival Neuralink’s enters clinical trials
Nature, Published online: 20 November 2025; doi:10.1038/d41586-025-03849-0Neurotechnology company Paradromics will test its device in a trial aimed at safely restoring...
I encourage women to claim their space in astrophysics and beyond
Nature, Published online: 21 November 2025; doi:10.1038/d41586-025-03400-1Debarati Chatterjee’s mission is to make science in India more welcoming towards women.
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