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Bacillus competence pili are efficient single - and double stranded DNA uptake machines
Natural competence describes the ability of several bacterial species to take up DNA from the environment for integration into the host chromosome, allowing the acquisi...
Histones and nucleoid-associated proteins in Methanosarcina acetivorans mediate recovery from stress and stasis
Many archaea encode both histones and Nucleoid-Associated Proteins (NAPs), which we refer to collectively as archaeal DNA Binding Proteins (DBPs). Whether these DBPs jo...
How to fix genetic ‘nonsense’: versatile gene-editing tool could tackle a host of diseases
Nature, Published online: 19 November 2025; doi:10.1038/d41586-025-03770-6Synthetic RNA molecules can program cells to ignore DNA mutations that interfere with protein...
Circular DNA has a ticket to ride chromosomes
Nature, Published online: 19 November 2025; doi:10.1038/d41586-025-03589-1How circular extrachromosomal DNA is inherited during cell division is a puzzle. Key sequences...
Genetic elements promote retention of extrachromosomal DNA in cancer cells
Nature, Published online: 19 November 2025; doi:10.1038/s41586-025-09764-8A combination of genome-wide functional screening, imaging and chromatin profiling identifies...
Semantic design of functional de novo genes from a genomic language model
Nature, Published online: 19 November 2025; doi:10.1038/s41586-025-09749-7By learning a semantics of gene function based on genomic context, the genomic language model...