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Sex-biased duplicates are rapidly generated during Drosophila tRNA repertoire evolution
Eukaryotic genomes encode hundreds of transfer RNA genes ostensibly to ensure efficient translation. How these seemingly redundant tRNA copies arise and are naturally s...
Bacillus competence pili are efficient single - and double stranded DNA uptake machines
Natural competence describes the ability of several bacterial species to take up DNA from the environment for integration into the host chromosome, allowing the acquisi...
Antiviral and anti-inflammatory effects of Tabamide A derivative, TA25, against human rhinovirus and multiple zoonotic viruses in vitro and in silico
Human rhinovirus (HRV), first isolated in 1956, belongs to the family Piconaviridae containing a positive-sense, single-stranded RNA genome. HRV causes mild cold and se...
General-Purpose Large Language Models, such as DeepSeek V3.2, Have Evolved Protein Design Capabilities
General-Purpose Large Language Models (GLLMs), although primarily developed for natural language processing, are increasingly demonstrating emergent capabilities in spe...
Lignin degradation and valorization by Pseudomonas putida KT2440: a new role for glutathione peroxidase
Lignin, a complex natural aromatic polymer, poses significant challenges to its efficient degradation, hindering the utilization of biomass for many industrial applicat...
Histones and nucleoid-associated proteins in Methanosarcina acetivorans mediate recovery from stress and stasis
Many archaea encode both histones and Nucleoid-Associated Proteins (NAPs), which we refer to collectively as archaeal DNA Binding Proteins (DBPs). Whether these DBPs jo...
Biophysical constraints on mRNA decay rates shape macroevolutionary divergence in steady-state abundances
Evolutionary changes to gene expression are understood to be a major driver of phenotypic divergence between species. Researchers have investigated the drivers of this...
Flavobacteria buffer nitrous oxide emissions from partial denitrifiers in coastal sediments
Nearly one-fifth of global emissions of the potent greenhouse gas nitrous oxide (N2O) originate from the ocean, particularly from nutrient-polluted coastal regions. Per...
Glycerol suppresses lactose-dependent growth of Streptococcus pyogenes through a transcription-independent mechanism
Streptococcus pyogenes (group A Streptococcus; GAS) requires flexible metabolic regulation to adapt to diverse host environments; however, its physiological responses t...
HIV Virion Capturing Liposomes for Therapeutic Vaccination
HIV infection currently has no effective cures and requires lifelong antiretroviral treatments. Cures have failed due to HIVs immune evasion and rapid mutation rate. He...
An ancient anthozoan protein reveals an alternative evolutionary path of antiviral signaling
How antiviral immunity first arose in animals is a central question in evolutionary biology. Using the sea anemone Nematostella vectensis, we identify CARDIB, a previou...
Bacteriophage genome-wide transposon mutagenesis
Bacteriophages have genomes that span a wide size range, are densely packed with coding sequences, and frequently encode genes of unknown function. Classical forward ge...
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