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人类结膜上皮细胞与巨噬细胞对沙眼衣原体A、B基因型在感染早中期周期反应的比较转录组分析
Chlamydia trachomatis (Ct), an obligate intracellular bacterium, is the primary infectious cause of blindness through trachoma. Ct undergoes a unique biphasic developme...
结核病患者肠道微生物组中双歧杆菌与大肠杆菌主导的生态群塑造独特的微生物代谢特征
Introduction Gut microbial community plays a key role in maintaining host immune homeostasis. However, current analytical approaches treat microbiomes at taxon-level an...
构建高效中心代谢途径，提升酵母生物合成能力且不抑制细胞生长
Long-term natural evolution selects glycolysis as the major metabolic mode for rapid cell growth, which however lacks sufficient NADPH supply to dive the biosynthesis o...
地热变形虫刷新真核生物生存温度上限
The study of temperature limits has transformed our knowledge of the boundaries of life but has been largely focused on bacteria and archaea. We isolated a novel geothe...
针对代谢弱点：缬氨霉素增强生物能量抑制剂对抗耐药与休眠结核分枝杆菌的效力
Tuberculosis (TB) treatment is hampered by monotherapy limitations and phenotypic drug tolerance, citing the need for effective drug combinations. The mycobacterial ele...
转录组学与蛋白质组学分析揭示氮循环是原绿球藻长期生存的核心机制
Prochlorococcus, the dominant cyanobacterium in the oligotrophic ocean, possesses a streamlined genome and depends on interactions with heterotrophic bacteria for survi...
高致病性禽流感A(H5)病毒分支2.3.2.1c和2.3.4.4持续进化导致血凝素基因分支命名更新
The evolutionary divergence of the A(H5) hemagglutinin (HA) gene of high pathogenicity avian influenza (HPAI) viruses (A/goose/Guangdong/96 lineage) was analyzed by phy...
人类星状病毒中病毒蛋白酶介导的多聚蛋白加工
Positive-sense RNA viruses often encode large polyproteins that are proteolytically processed by viral and host proteases into functional replication proteins. Astrovir...
揭示公共与私有T细胞受体识别肽的结构决定因素
Public T cell receptors (TCRs) recurrently emerge across individuals in response to common pathogens, yet the structural and biophysical basis distinguishing public fro...
仲裁系统通过调控小抗阻遏蛋白来控制裂解/溶原性决策
Many temperate Bacillus phages utilize the arbitrium signaling system to control lysis/lysogeny decisions. While the function of the arbitrium signal AimP and its recep...
热与非热应激条件激活恶性疟原虫AP2-HS依赖性热休克反应
To preserve proteome homeostasis and survive at higher-than-optimal temperatures, organisms have evolved the conserved heat shock (HS) response (HSR), characterised by...
石胆酸诱导依赖T3SS形成具有侵袭能力的福氏志贺氏菌聚集物
Shigella flexneri causes shigellosis, the second leading cause of diarrheal deaths worldwide. The pathogen invades colonic epithelial cells using a type III secretion s...
基于口腔微生物组的食管鳞状细胞癌跨大陆普适性预测模型
Esophageal squamous cell carcinoma (ESCC) is a disease with limited tools for early screening and a poor prognosis. Symptoms typically appear late, and early cancer is...
博物馆收藏的Diadema Antillarum中盾纤毛虫检测与微生物组构成分析
Background. The mass mortality of the long-spined sea urchin Diadema antillarum has caused widespread ecological changes across Caribbean reefs, with recent studies ide...
针对牛病原体莫拉氏菌的新型噬菌体特性研究
Background: Infectious bovine keratoconjunctivitis is the most important cattle ocular disease worldwide. The infection is primarily caused by Moraxella bovis and is a...
基于GRAd载体的新冠与HIV疫苗的非临床安全性支持平台监管策略
The rapid development of safe and efficacious vaccines is often hindered by extensive, mandated non-clinical safety evaluations in animals. Here we present the complete...
基于miRNA-mRNA2三链体介导核糖体移码的可编程mRNA平台用于miRNA检测
Programmed -1 ribosomal frameshifting (-1 PRF) is a recoding mechanism utilized by viruses to expand their coding capacity and modulate the stoichiometric ratio of -1 f...
坦桑尼亚伊法卡拉新建立的富氏按蚊实验室种群特征研究
Background: Anopheles funestus, a major vector of malaria in Africa, has proven difficult to colonize in laboratory settings, impeding research on its biology and contr...
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