对刺胞动物<i>Nematostella vectensis</i>中RNA干扰机制的研究揭示部分靶标沉默现象，但缺乏小RNA扩增过程。
Characterization of RNA interference in the cnidarian Nematostella vectensis reveals partial target silencing but lack of small RNA amplification
生命科学资讯
生物技术与制药领域的最新动态
小鼠中Rho GTPase调节因子ARHGEF3通过协调细胞命运与P-钙黏蛋白模式调控毛囊基板萌芽
The Rho GTPase regulator ARHGEF3 orchestrates hair placode budding by coordinating cell fate and P-cadherin patterning in mice
MMSpa是一款基于深度学习的工具，旨在提升空间转录组学研究中空间区域的识别能力。
MMSpa is a deep learning-based tool that enhances the identification of spatial domains in spatial transcriptomics studies
Foxi1通过转录与表观遗传机制调控多潜能粘液纤毛祖细胞及离子细胞分化
Foxi1 regulates multipotent mucociliary progenitors and ionocyte specification through transcriptional and epigenetic mechanisms
H5N1流感病毒在奶牛感染期间动力学模型揭示传染性时机
Modeling of H5N1 influenza virus kinetics during dairy cattle infection suggests the timing of infectiousness
维持成年果蝇的性身份是一项持续的任务
Maintaining sexual identity in adult flies is an ongoing commitment
衰老相关过氧化物酶体失调通过改变极长链脂肪酸氧化破坏肠道干细胞分化
Aging-related peroxisomal dysregulation disrupts intestinal stem cell differentiation through alterations of very long-chain fatty acid oxidation
斑马鱼肠道内分泌细胞亚型及其相关激素的鉴定
Identification of intestinal enteroendocrine cell subtypes and their associated hormones in zebrafish
转录后抑制先锋因子Zelda保护成年果蝇睾丸免受卵巢程序激活
Post-transcriptional suppression of the pioneer factor Zelda protects the adult Drosophila testis from activation of the ovary program
主毒力调控因子PhoP通过控制环状AMP合成来调控沙门氏菌的碳代谢
The master virulence regulator PhoP dictates carbon metabolism by controlling cyclic AMP synthesis in Salmonella
Slitrk细胞粘附分子同源物通过不同细胞机制配置兴奋性突触特异性
Paralogs of Slitrk cell adhesion molecules configure excitatory synapse specificity via distinct cellular mechanisms
2025：坚韧与智慧并存之年
2025: A year of resilience and resourcefulness
若以文章层面指标评估，多数研究者将获得更多认可。
Most researchers would receive more recognition if assessed by article-level metrics than by journal-level metrics
受细菌种群结构驱动的有偏采样混淆了机器学习对抗菌素耐药性的预测
Biased sampling driven by bacterial population structure confounds machine learning prediction of antimicrobial resistance
果蝇逃避运动回路呈现与功能衰退相关的衰老差异脆弱性
The Drosophila escape motor circuit shows differential vulnerability to aging linked to functional decay
USPPAR是一种经济高效、可扩展且高度敏感的单细胞RNA测序工作流程，适用于多种样本类型。
USPPAR is a cost-effective, scalable, and highly sensitive single-cell RNA sequencing workflow compatible with diverse specimens
细菌基因5′端突变率异常，可能误导自然选择测试
Bacterial gene 5′ ends have unusual mutation rates that can mislead tests of selection
双重信号协同调控红细胞生成：为何一加一大于二？
When two signals are better than one: Synergistic control of erythropoiesis
炭疽芽孢杆菌孢子形成基因的鉴定揭示其与枯草芽孢杆菌的相似性与显著差异
Identification of sporulation genes in Bacillus anthracis highlights similarities and significant differences with Bacillus subtilis
上皮转录因子GRHL2的去抑制促进肝细胞直接向胆管细胞转分化
Derepression of the epithelial transcription factor GRHL2 promotes direct hepatocyte-to-cholangiocyte transdifferentiation