生命科学资讯

Cell2Spatial is a computational framework that maps single cells to spatial transcriptomic spots to reconstruct tissue architecture

The cell cycle regulator PLK1 promotes murine melanoma progression by regulating the transcription factor BACH1

Amyloid precursor protein modulates cerebellar Purkinje cell activity and motor function through regulation of Nav1.6 currents

Reprogramming of microspore fate via BBM-BAR1 for highly efficient in vivo haploid induction

Unveiling conformation-selective regulation of the norepinephrine transporter

Adrenergic signaling coordinates distant and local responses to amputation in axolotl

Bacterial tubular networks channel carbohydrates in insect endosymbiosis

A de novo-originated gene drives rose scent diversification

Cancer cells co-opt an inter-organ neuroimmune circuit to escape immune surveillance

ABP1/ABL3-TMK1 cell-surface auxin signaling targets PIN2-mediated auxin fluxes for root gravitropism

Systemic immune activity occurs during human immune system maturation

A single-nucleus transcriptomic atlas of the adult Aedes aegypti mosquito

Adenosine kinase and ADAL coordinate detoxification of modified adenosines to safeguard metabolism

De novo design of a peptide modulator to reverse sodium channel dysfunction linked to cardiac arrhythmias and epilepsy

Multiscale proteomic modeling reveals protein networks driving Alzheimer’s disease pathogenesis

Human monoclonal antibodies targeting A35 protect from death caused by mpox

IL-25-induced memory type 2 innate lymphoid cells enforce mucosal immunity

Transient gene melting governs the timing of oligodendrocyte maturation

Structural basis of poxvirus fusion regulation and anti-A16/G9 antibody-mediated neutralization and protection

Structurally conserved human anti-A35 antibodies protect mice and macaques from mpox virus infection