生命科学资讯

Efficient amyloid-β degradation in Alzheimer’s disease using SPYTACs

Genetically encoded fluorescent reporters to visualize α-synuclein pathology in live brain

Restoring circadian rhythms in the hypothalamic paraventricular nucleus reverses aging biomarkers and extends lifespan in male mice

The adaptor protein TASL is required for age-related B cell emergence and lupus-like disease development in mice

UCB boards T cell engager train in $60M upfront deal with Antengene

Deep learning linking mechanistic models to single-cell transcriptomics data reveals transcriptional bursting in response to DNA damage

SLC4A1 mutations that cause distal renal tubular acidosis alter cytoplasmic pH and cellular autophagy

Pierre Fabre seeks to revive US approval chances for spurned cell therapy

Intracellular expression of a fluorogenic DNA aptamer using retron Eco2

Why it’s critical to close open steps in cell therapy manufacturing

Citrate clearance is a major function of aconitase 2 in the canonical TCA cycle

Pyruvate is a natural suppressor of interferon signaling by inducing STAT1 protein pyruvylation

High-resolution in situ structures of hantavirus glycoprotein tetramers

As CAR-T cell therapy gains ground on solid tumors, regulatory red tape hinders progress

Genetic network shaping Kenyon cell identity and function in Drosophila mushroom bodies

Single-cell ultra-high-throughput multiplexed chromatin accessibility and gene expression sequencing (SUM-seq) - Nature

Organism-wide cellular dynamics and epigenomic remodeling in mammalian aging | Science

A cellular basis for the mammalian nocturnal-diurnal switch | Science

Reconstitution of sex determination and the testicular niche using mouse pluripotent stem cells | Science

A Live-Cell NanoBRET Assay Shines Light on Toxic RNA–Protein Interactions in Myotonic Dystrophy