生命科学资讯

Doubling dolutegravir dosage reduces the viral reservoir in ART-treated people with HIV

HIV-specific CD8+ T-cell proliferative response 24 weeks after early antiretroviral therapy initiation is associated with the subsequent reduction in the viral reservoir

The IBEX knowledge-base a community resource enabling adoption and development of immunofluorescence imaging methods

Robust assessment of asymmetric division in colon cancer cells

Computational modelling identifies key determinants of subregion-specific dopamine dynamics in the striatum

A titin missense variant drives atrial electrical remodeling and is associated with atrial fibrillation

Feedback of peripheral saccade targets to early foveal cortex

The cellular logic of limb regeneration

Western lifestyle linked to maladaptive trained immunity

Shifting the PPARγ conformational ensemble toward a transcriptionally repressive state improves covalent inhibitor efficacy

Anti-resonance in developmental signaling regulates cell fate decisions

cxcl18b-defined transitional state-specific nitric oxide drives injury-induced Müller glia cell-cycle re-entry in the zebrafish retina

Ω-Loop mutations control dynamics of the active site by modulating the hydrogen-bonding network in PDC-3 β-lactamase

Identification of a sub-population of synovial mesenchymal stem cells with enhanced treatment efficacy in a rat model of osteoarthritis

ATAD2 mediates chromatin-bound histone chaperone turnover

Modeling and simulation of neocortical micro- and mesocircuitry (Part I, anatomy)

Modeling and simulation of neocortical micro- and mesocircuitry (Part II, Physiology and experimentation)

Single-cell profiling of trabecular meshwork identifies mitochondrial dysfunction in a glaucoma model that is protected by vitamin B3 treatment

GMCL1 controls 53BP1 stability and modulates taxane sensitivity

A high-resolution analysis of arrestin2 interactions responsible for CCR5 endocytosis