糖酵解依赖性硫代谢调控真菌形态可塑性与毒力
Glycolysis-dependent sulfur metabolism orchestrates morphological plasticity and virulence in fungi
生命科学资讯
生物技术与制药领域的最新动态
单一微小RNA miR-195可挽救由EBF1缺陷引起的B细胞发育停滞
A single microRNA miR-195 rescues the arrested B cell development induced by EBF1 deficiency
通过小分子调节TFAM抑制干扰素信号通路
Suppression of interferon signaling via small-molecule modulation of TFAM
异时转录因子表达驱动十三纹地松鼠视锥细胞主导视网膜发育
Heterochronic transcription factor expression drives cone-dominant retina development in 13-lined ground squirrels
Ly6G<sup>+</sup>粒细胞来源的IL-17限制宿主保护性反应并促进结核病发病机制
Ly6G+ granulocytes-derived IL-17 limits protective host responses and promotes tuberculosis pathogenesis
背腹介导的<i>Shh</i>诱导是蝾螈肢体再生所必需的
Dorsoventral-mediated Shh induction is required for axolotl limb regeneration
更正：Gq活性与β-arrestin-1支架介导的ADGRG2/CFTR偶联对男性生育能力至关重要
Correction: Gq activity- and β-arrestin-1 scaffolding-mediated ADGRG2/CFTR coupling are required for male fertility
ZFT是弓形虫中铁和锌的主要转运蛋白
ZFT is the major iron and zinc transporter in Toxoplasma gondii
一款高分辨率、易搭建的光片显微镜，专用于亚细胞成像。
A high-resolution, easy-to-build light-sheet microscope for subcellular imaging
X射线照射后果蝇翅盘单细胞转录组学揭示与细胞周期状态和细胞位置相关的异质性。
Single-cell transcriptomics of X-ray irradiated Drosophila wing discs reveals heterogeneity related to cell-cycle status and cell location
脂质挑战配体以调控受体
Lipids challenge ligands to control receptors
抑制PRMT活性增强同源重组功能正常的卵巢癌和乳腺癌细胞对PARP抑制剂的敏感性
Repression of PRMT activities sensitize human homologous recombination-proficient ovarian and breast cancer cells to PARP inhibitor treatment
染色质重塑因子CHD4调控转录因子结合，既防止沉默增强子激活，又维持活跃调控元件的功能。
The chromatin remodeller CHD4 regulates transcription factor binding to both prevent activation of silent enhancers and maintain active regulatory elements
灵活人类运动的自动学习机制
Automatic learning mechanisms for flexible human locomotion
果蝇EGF域蛋白uninflatable受Notch指令调控，决定包裹胶质细胞生长与轴突包裹的转换开关
The Drosophila EGF domain protein uninflatable sets the switch between wrapping glia growth and axon wrapping instructed by Notch
混合物辨别训练诱导持久且泛化的嗅觉学习，不受气味结构和浓度影响。
Mixture discrimination training induces durable and generalizable olfactory learning independent of odorant structure and concentration
对成熟小鼠跟腱的单核转录与染色质可及性分析揭示肌腱干/祖细胞的分子景观
Single-nucleus transcriptional and chromatin accessibility analyses of maturing mouse Achilles tendon uncover the molecular landscape of tendon stem/progenitor cells
信息、确定性与学习
Information, certainty, and learning
HLA-DRA基因内含子1多态性差异关联1型糖尿病与乳糜泻，并提示补体系统基因C4A和C4B的参与
Polymorphisms in intron 1 of HLA-DRA differentially associate with type 1 diabetes and celiac disease and implicate involvement of complement system genes C4A and C4B
MRI技术瞄准胶原蛋白研究
MRI sets its sights on collagen