生命科学资讯
生物技术与制药领域的最新动态
脂质挑战配体以调控受体
Lipids challenge ligands to control receptors
抑制PRMT活性增强同源重组功能正常的卵巢癌和乳腺癌细胞对PARP抑制剂的敏感性
Repression of PRMT activities sensitize human homologous recombination-proficient ovarian and breast cancer cells to PARP inhibitor treatment
染色质重塑因子CHD4调控转录因子结合,既防止沉默增强子激活,又维持活跃调控元件的功能。
The chromatin remodeller CHD4 regulates transcription factor binding to both prevent activation of silent enhancers and maintain active regulatory elements
灵活人类运动的自动学习机制
Automatic learning mechanisms for flexible human locomotion
果蝇EGF域蛋白uninflatable受Notch指令调控,决定包裹胶质细胞生长与轴突包裹的转换开关
The Drosophila EGF domain protein uninflatable sets the switch between wrapping glia growth and axon wrapping instructed by Notch
混合物辨别训练诱导持久且泛化的嗅觉学习,不受气味结构和浓度影响。
Mixture discrimination training induces durable and generalizable olfactory learning independent of odorant structure and concentration
对成熟小鼠跟腱的单核转录与染色质可及性分析揭示肌腱干/祖细胞的分子景观
Single-nucleus transcriptional and chromatin accessibility analyses of maturing mouse Achilles tendon uncover the molecular landscape of tendon stem/progenitor cells
信息、确定性与学习
Information, certainty, and learning
HLA-DRA基因内含子1多态性差异关联1型糖尿病与乳糜泻,并提示补体系统基因C4A和C4B的参与
Polymorphisms in intron 1 of HLA-DRA differentially associate with type 1 diabetes and celiac disease and implicate involvement of complement system genes C4A and C4B
MRI技术瞄准胶原蛋白研究
MRI sets its sights on collagen
面部情绪表征随发育从感觉皮层扩展至前额叶皮层。
The representation of facial emotion expands from sensory to prefrontal cortex with development
通过中脑实现谨慎行为的前脑枢纽
A forebrain hub for cautious actions via the midbrain
左额上沟在人类感知决策中特定领域作用的因果证据
Causal evidence for a domain-specific role of left superior frontal sulcus in human perceptual decision-making
铜绿假单胞菌网络化元种群中的加速进化
Accelerated evolution in networked metapopulations of Pseudomonas aeruginosa
人脑在威胁处理过程中的动态与时空轨迹
Human brain dynamics and spatiotemporal trajectories during threat processing
撤稿:颅脑照射后PAK3下调导致认知功能障碍
Retraction: PAK3 downregulation induces cognitive impairment following cranial irradiation
单细胞转录组学揭示烟草味电子烟暴露小鼠肺部中性粒细胞动态改变及T细胞毒性加剧
Single-cell transcriptomics identifies altered neutrophil dynamics and accentuated T-cell cytotoxicity in tobacco-flavored e-cigarette-exposed mouse lungs
更正:下调的GAS6损害滑膜巨噬细胞胞葬作用并促进肥胖相关骨关节炎
Correction: Down-regulated GAS6 impairs synovial macrophage efferocytosis and promotes obesity-associated osteoarthritis
固着与游动纤毛虫的摄食率在流体动力学上等效
Feeding rates in sessile versus motile ciliates are hydrodynamically equivalent