生命科学资讯
生物技术与制药领域的最新动态
First-in-class fusion protein reverses T-cell exhaustion across multiple models
赛默飞世尔科技推出简化肝细胞基因表达试剂盒,助力早期药物发现进程——SelectScience报道。
Thermo Fisher Scientific launches kit to simplify liver cell gene expression and help advance early-stage drug discovery - SelectScience
Single-cell transcriptomics of X-ray irradiated Drosophila wing discs reveals heterogeneity related to cell-cycle status and cell location
查尔斯河将关闭细胞疗法CDMO基地,裁员20名员工。
Charles River to close cell therapy CDMO site, lay off 20 staffers
抑制PRMT活性增强同源重组功能正常的卵巢癌和乳腺癌细胞对PARP抑制剂的敏感性
Repression of PRMT activities sensitize human homologous recombination-proficient ovarian and breast cancer cells to PARP inhibitor treatment
10x Genomics推出高通量单细胞检测,扩展Flex产品线 - MSN
10x Genomics Expands Flex Lineup with High-Throughput Single-Cell Assay Launch - MSN
构建稳健的细胞疗法制造过程测试计划以确保成功
Building a robust in-process testing plan for cell therapy manufacturing success
对成熟小鼠跟腱的单核转录与染色质可及性分析揭示肌腱干/祖细胞的分子景观
Single-nucleus transcriptional and chromatin accessibility analyses of maturing mouse Achilles tendon uncover the molecular landscape of tendon stem/progenitor cells
人类病理性tau蛋白的分子特征区分与tau蛋白病相关的痴呆症
Molecular features of human pathological tau distinguish tauopathy-associated dementias
人类眶额叶神经活动与强迫症行为动态密切相关
Human orbitofrontal neural activity is linked to obsessive-compulsive behavioral dynamics
交感-上皮细胞交互调控皮肤组织驻留记忆T细胞的免疫监视功能。
Sympathetic-epithelial crosstalk governs tissue-resident memory T cell immunosurveillance in the skin
癌症标志——过去与现在,以及未来展望
Hallmarks of cancer—Then and now, and beyond
Janux任命首席营销官,此前与百时美施贵宝达成T细胞衔接器协议;Lexeo一批新任命出炉
Janux hires CMO after T cell engager deal with Bristol Myers; A batch of appointments at Lexeo
通过分层交叉熵损失改进图谱规模单细胞注释模型 - 《自然》
Improving atlas-scale single-cell annotation models with hierarchical cross-entropy loss - Nature
Ro60与La自身抗原的RNA伴侣机制解析
Mechanistic insights into RNA chaperoning by Ro60 and La autoantigens
一种用于构建体内吸收不良生物传感器的拟杆菌合成生物学工具包
A Bacteroides synthetic biology toolkit to build an in vivo malabsorption biosensor
CRISPR筛选揭示iPSC衍生神经元中tau蛋白稳态调控机制
CRISPR screens in iPSC-derived neurons reveal principles of tau proteostasis
RFC在PCNA介导的进程性DNA合成中的非催化作用
A non-catalytic role for RFC in PCNA-mediated processive DNA synthesis
阿斯利康承诺在华投资150亿美元,增强细胞疗法与放射性药物研发能力。
AstraZeneca vows $15B China investment to boost cell therapy and radioconjugate capabilities