生命科学资讯

Charles River to close cell therapy CDMO site, lay off 20 staffers

Repression of PRMT activities sensitize human homologous recombination-proficient ovarian and breast cancer cells to PARP inhibitor treatment

Building a robust in-process testing plan for cell therapy manufacturing success

Single-nucleus transcriptional and chromatin accessibility analyses of maturing mouse Achilles tendon uncover the molecular landscape of tendon stem/progenitor cells

Molecular features of human pathological tau distinguish tauopathy-associated dementias

Human orbitofrontal neural activity is linked to obsessive-compulsive behavioral dynamics

Sympathetic-epithelial crosstalk governs tissue-resident memory T cell immunosurveillance in the skin

Hallmarks of cancer—Then and now, and beyond

Janux hires CMO after T cell engager deal with Bristol Myers; A batch of appointments at Lexeo

Improving atlas-scale single-cell annotation models with hierarchical cross-entropy loss - Nature

Mechanistic insights into RNA chaperoning by Ro60 and La autoantigens

A Bacteroides synthetic biology toolkit to build an in vivo malabsorption biosensor

CRISPR screens in iPSC-derived neurons reveal principles of tau proteostasis

A non-catalytic role for RFC in PCNA-mediated processive DNA synthesis

AstraZeneca vows $15B China investment to boost cell therapy and radioconjugate capabilities

Single-cell transcriptomics identifies altered neutrophil dynamics and accentuated T-cell cytotoxicity in tobacco-flavored e-cigarette-exposed mouse lungs

A GPCR-G protein-β-arrestin megacomplex enabled by a versatile allosteric modulator

Field-effect-informed urine liquid biopsy for bladder cancer

AAVLINK: A potent DNA-recombination method for large cargo delivery in gene therapy

An uORF-encoded mobile peptide sparks systemic stomatal immunity