生命科学资讯

TRPV3 channel activity helps cortical neurons stay active during fever

Inhibitory circuits control leg movements during Drosophila grooming

Microglia replacement by ER-Hoxb8 conditionally immortalized macrophages provides insight into Aicardi–Goutières syndrome neuropathology

Directed differentiation of functional corticospinal-like neurons from endogenous SOX6+/NG2+ cortical progenitors

Synaptic mechanisms modulate the spatiotemporal dynamics of striatal direct pathway neurons and motor output

Axonal distribution of mitochondria maintains neuronal autophagy during aging via eIF2β

Phenylhydrazone-based endoplasmic reticulum proteostasis regulator compounds with enhanced biological activity

Doubling dolutegravir dosage reduces the viral reservoir in ART-treated people with HIV

HIV-specific CD8+ T-cell proliferative response 24 weeks after early antiretroviral therapy initiation is associated with the subsequent reduction in the viral reservoir

The IBEX knowledge-base a community resource enabling adoption and development of immunofluorescence imaging methods

Robust assessment of asymmetric division in colon cancer cells

Computational modelling identifies key determinants of subregion-specific dopamine dynamics in the striatum

A titin missense variant drives atrial electrical remodeling and is associated with atrial fibrillation

Feedback of peripheral saccade targets to early foveal cortex

The cellular logic of limb regeneration

Western lifestyle linked to maladaptive trained immunity

Shifting the PPARγ conformational ensemble toward a transcriptionally repressive state improves covalent inhibitor efficacy

Anti-resonance in developmental signaling regulates cell fate decisions

cxcl18b-defined transitional state-specific nitric oxide drives injury-induced Müller glia cell-cycle re-entry in the zebrafish retina

Ω-Loop mutations control dynamics of the active site by modulating the hydrogen-bonding network in PDC-3 β-lactamase